Mayo Clinic is creating a library of genomic sequencing data on 100,000 consented Mayo Clinic participants to advance research and patient care. Participants’ DNA will be sequenced using Helix’s Exome+ assay. Participants in this study, known as Tapestry, will receive genetic screening results for three highly actionable hereditary conditions that often go unrecognized, including familial hypercholesterolemia (FH), hereditary breast and ovarian cancer (BRCA1 and BRCA2), and Lynch syndrome, a form of hereditary colorectal cancer. Over time, results will be returned to Tapestry participants and their Mayo Clinic provider. This will allow Mayo Clinic to evaluate the benefits of Exome+ sequencing and the short- and long-term impact on health-related outcomes, health care utilization, and physician acceptance.