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Accelerating Therapeutic Development

Autoimmune diseases clinico-genomic registry

Unleash the world’s most dynamic precision clinical research network and optimize drug development by accessing Helix’s rapidly growing autoimmune clinico-genomic registry. By integrating rich clinical data with deep genomic insights via exome sequencing from a diverse patient population, our dataset is designed to help researchers better understand autoimmune disease mechanisms, identify and validate drug targets, and help identify targeted patient populations based on genetic and phenotypic criteria for therapeutic development.

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A diverse and rapidly growing Autoimmune disease cohort

Autoimmune disease affects approximately 50 million Americans (~15% of the population), and has been on the rise in recent years. Built as part of the Helix Research Network (HRN), the cohort consists of whole Exome+® sequencing profiles for 23,000 individuals with conditions such as Lupus, Rheumatoid Arthritis (RA), Psoriasis, Multiple Sclerosis (MS), Hashimoto's disease, Crohn's and many more, lab results, & procedures, as well as linked medical and pharmacy claims data.

Cohort Highlights

>15 Autoimmunte Results

Agents included: >15 autoimmune lab results including antinuclear antibody (ANA) tests, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and more

>23,000 Cohort

Cohort Size: >23K consented Autoimmune disease patients including RA, Lupus, MS, Psoriasis, Hashimoto’s and many more

~ 15yrs lookback

Average patient EHR history: ~15yrs lookback including diagnoses, lab results, prescriptions and much more

Longitudinal Clinical Insights

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Research Insights

Inflammatory Bowel Disease (IBD), including Crohn’s disease and Ulcerative Colitis impacts millions of people in the US. Conventional treatments are currently limited to reducing inflammation, however personalized treatment can offer options to treat the disease directly. Using data from the Helix Research Network, Helix scientists recently presented an analysis at the ASHG conference on the genetics of Crohn’s disease, and in particular the NOD2 gene where mutations in the gene have been associated with Crohn’s disease and other conditions.

Helix Advantages

Longitudinal Clinical Insights

De-identified, OMOP-standardized EHR integrations, including full clinical data & lab results, across North America. Regular data refreshes enable life sciences to follow the patient journey beyond an initial encounter.

Whole Exome+ Sequencing

Deep genomic insights using Helix’s comprehensive and proprietary exome platform covering hundreds of genes implicated in cardiovascular, metabolic, and other related diseases.

Patient Consent

Full consent for recontact for enrollment in research studies, clinical trials, and surveys.

World class Analytical Capabilities

Dedicated in-house translational research team to support life sciences’ analytical and research needs.

Additional Resources

Press Releases

Helix Launches 23,000-Patient Clinico-Genomic Cohort for Autoimmune Diseases to Advance Drug Discovery and Development

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Helix Research Blog

American Society of Human Genetics 2024 Posters

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Webinars

The Future of Precision Medicine: Leveraging Clinico-Genomic Data for Germline Disorders

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