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BRCA1 and BRCA2 Panel

A 2-gene panel for evaluating hereditary breast and ovarian cancer (HBOC) risk, powered by the Helix Exome+® platform for comprehensive BRCA1 and BRCA2 analysis.

Turnaround

6-21 days

Turnaround Requery

≤ 5 days

Panel Description

This panel evaluates 2 genes associated with hereditary breast and ovarian cancer (HBOC).

Have Questions?

Our team is available Monday through Friday, 9am-5pm Pacific Time.

Indications for Testing

A relevant personal and/or family history suggestive of a hereditary form of cancer.

Methodology

This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary breast and ovarian cancer (HBOC).

Technical Specifications

Analytical sensitivity (SNV)

> 99%

Analytical sensitivity (indel)

> 99%

Analytical specificity

> 99%

CNV sensitivity (multi-exon)

> 99%

CNV sensitivity (single-exon)

> 90%

Gene notes

BRCA1: sequencing analysis extends to CDS +/-20 bp; BRCA2: analysis includes detection of c.156_157insAlu and sequencing analysis extends to CDS +/-20 bp....

Genomic build

GRCh38

Genes Tested

BRCA1
BRCA2

Showing 2 of 2 genes in this panel

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