CLINICAL GENOMICS
Powering modern genomic medicine
Helix combines advanced sequencing, AI-powered classification, and the largest clinical genomics network to deliver diagnostic answers today—and lifetime value for your patients.
The Foundation
Clinical-grade sequencing. Built for what comes next.
The Helix laboratory is one of the largest clinical genomics facilities in North America, processing tens of thousands of samples monthly with industry-leading turnaround times.
Exome+® Assay – Comprehensive exome with enhanced clinical regions
Multi-Modal Capability – Short-read and long-read whole genome sequencing
Sequence Once, Query Often® – One sample becomes a lifetime of queryable data
CAP/CLIA Validated – >99% sensitivity, 99% concordance
The Intelligence
20+ AI Agents. Working in Parallel. Reasoning at Scale.
Wayfinder™ is Helix's proprietary interpretation engine—a swarm of specialized AI agents that interrogate every variant in Helix’s assay against global clinical evidence, then synthesize findings using ACMG/AMP guidelines.
Parallel Agent Architecture – Gene validity, population data, in-silico predictions, phenotype matching, literature mining, functional evidence—simultaneously
Continuous Evidence Monitoring – Continual surveillance of PubMed, ClinVar, gnomAD
Explainable Reasoning – Every classification shows its evidence chain
Expert Validation – Final review by board-certified geneticists
Wayfinder Core
ACTIVE_SESSION
The Data Advantage
Population-scale evidence. Powering Every Interpretation.
The Helix Research Network® is one of the largest clinicogenomic research registries in existence—comprising an expansive community of patients with linked genomic and EHR data. When Wayfinder evaluates a variant, it queries real-world evidence: actual patient outcomes, true clinical penetrance, population-specific frequencies.
Clinicogenomic Scale – Vast cohorts with exome data + longitudinal EHR
Real-World Evidence – How variants actually manifest in real patients
Population Diversity – Representative of real-world clinical populations
Continuous Enrichment – Every test strengthens the network
Sequence Once, Query Often® Architecture