Circadian rhythm is an interesting biological phenomenon—it is a natural tendency of an organism to stick to a repeated cycle of wake and sleep. In humans, this cycle is roughly 24 hours long and results in an average bedtime of between 10:00pm and 12:00am, and wake time between 6:00 and 8:00am. But not everyone follows this schedule.
Some causes of a shifted circadian rhythm are due to factors you can control. Traveling across time zones, having an infant, or working a night shift can all cause someone to influence their internal clock and adopt a different circadian rhythm. But for some people, genetic factors have a natural influence the time they fall asleep and wake up.
These individuals may a hard time falling asleep before 3:00am and sometimes wake up in the late morning. People with a shifted circadian rhythm may have trouble adapting to a typical daytime work schedule.
To determine if you have a shifted circadian rhythm due to inherited genetic factors, Helix looks at a single variant, rs184039278, in the CRY1 gene. Individuals that have a C at this position are very likely to have a shifted circadian rhythm or fragmented sleep (meaning brief periods of sleep during the night supplemented by naps during the day). In contrast to other insights, your genetic results are a very good predictor of your experience.
But having a C at this position is quite rare. Only 0.2-0.3% of people have CT or CC genotypes, and it is not found equally across all populations. Only people of European or Indigenous American ancestry are likely to have a C at this position.
Blog
How does Helix calculate your Circadian Rhythm result?
June 18, 2018

Ready to see the whole picture?
Connect with our team to discover how Helix can transform your approach to genomic medicine.