The future of genomics programs is already here.
High-quality sequencing is table stakes. What sets Helix apart is what happens after; Sequence Once, Query Often®, population-level real-world evidence powered by millions of samples, and continuous evidence and interpretation with Helix Wayfinder™.
Exome+® Assay
Comprehensive exome with enhanced clinical regions.
CAP / CLIA certified
>99% sensitivity, 100% concordance across variant classes.
Multi-Modal Capability
Short-read and long-read whole genome sequencing.
Sequence Once, Query Often®
One sample becomes a lifetime of queryable data — no re-collection, no re-sequencing. Order new panels instantly on existing data.
Population-scale RWE
The Helix Research Network® resolves 45% of VUS that remain uncertain elsewhere — 96% confirmed benign, 9% increase in pathogenic calls.
Read the researchAI-powered interpretation
Wayfinder™ deploys 20+ specialized AI agents in parallel to classify variants against global clinical evidence using ACMG/AMP guidelines.
20+ AI agents. Working in parallel. Reasoning at scale.
Wayfinder™ is Helix's proprietary interpretation engine — a swarm of specialized AI agents that interrogate every variant against global clinical evidence, then synthesize findings using ACMG/AMP guidelines.
- Parallel agent architecture
Gene validity, population data, in-silico predictions, phenotype matching, literature mining, functional evidence — simultaneously.
- Continuous evidence monitoring
Continual surveillance of PubMed, ClinVar, gnomAD for new evidence.
- Explainable reasoning
Every classification shows its complete evidence chain for transparency.
- Expert validation
Final review by board-certified geneticists ensures clinical-grade accuracy.
Population-scale evidence. Powering every interpretation.
The Helix Research Network is one of the largest clinicogenomic databases in existence — comprising an expansive community of patients with linked genomic and EHR data.
- Clinicogenomic scale
Vast cohorts with exome data + longitudinal EHR.
- Real-world evidence
How variants actually manifest in real patients.
- Population diversity
Representative of real-world clinical populations.
- Continuous enrichment
Every test strengthens the network.
See the science in action
Schedule a walkthrough with our clinical team to learn how Helix's platform can transform your genomics practice.