Hereditary Comprehensive Cancer Panel
A comprehensive 70+ gene panel designed to identify hereditary cancer syndromes across multiple tumor types, enabling proactive surveillance and cascade screening.
Turnaround
6–21 days
Requery (SOQO)
≤ 5 days
Genes Tested
70
Panel Description
The Hereditary Comprehensive Cancer Panel analyzes 70+ genes associated with hereditary cancer syndromes. This panel is designed for patients with a personal or family history suggestive of hereditary cancer, and provides clinically actionable results to guide surveillance, risk-reduction strategies, and cascade screening of at-risk family members.
Order This Test
Contact our clinical team to order this panel or learn more.
Indications for Testing
Recommended for individuals with a personal or family history of cancer that meets NCCN criteria for genetic testing, including but not limited to: breast cancer diagnosed before age 50, ovarian cancer at any age, multiple primary cancers, colorectal or endometrial cancer with MSI/IHC findings suggestive of Lynch syndrome, or a known family mutation in a cancer predisposition gene.
Methodology
Clinical-grade Exome+® sequencing with enhanced coverage of medically relevant non-coding regions. Includes sequence analysis and deletion/duplication analysis for all genes on the panel. Variants are interpreted per ACMG/AMP guidelines with Wayfinder™ AI-assisted curation.
Technical Specifications
Analytical Sensitivity
>99.9% for SNVs and small indels
Analytical Specificity
>99.9%
CNV Detection
Exon-level resolution for all panel genes
Sequencing Platform
Exome+® (Illumina)
Interpretation Engine
Wayfinder™ AI + Board-Certified Geneticists
Genomic Build
GRCh38 (hg38)
Genes Tested
70 genes included in this panel
Ordering Information
Turnaround Time
Typically 7–21 days (standard), Typically < 5 days (requery)
Preferred Specimen
BD Vacutainer Whole Blood K2 EDTA Collection Tube 4mL or Oragene Dx Saliva Collection Kit
Shipping Instructions
Specimens to arrive at Helix within 96 hours of collection at ambient temperature.
Clinical Description
The Hereditary Comprehensive Cancer Panel covers genes associated with a wide spectrum of hereditary cancer syndromes, including hereditary breast and ovarian cancer, Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis, and others.
Pathogenic variants in these genes are associated with significantly increased lifetime risks of various cancer types and may guide preventive measures such as enhanced surveillance, risk-reducing surgeries, and targeted therapeutics.
This panel uses Helix's Exome+® platform, which sequences the entire exome plus medically relevant non-coding regions, providing a comprehensive genomic dataset that can be requeried for additional indications in the future via SOQO®.
All results are interpreted by board-certified clinical geneticists with AI-assisted variant curation through Wayfinder™, ensuring high accuracy and clinical relevance.
Ready to order this test?
Contact our clinical team to order the Hereditary Comprehensive Cancer Panel for your patients.