BRCA1 and BRCA2 Panel
A 2-gene panel for evaluating hereditary breast and ovarian cancer (HBOC) risk, powered by the Helix Exome+® platform for comprehensive BRCA1 and BRCA2 analysis.
Turnaround
6-21 days
Requery (SOQO)
≤ 5 days
Genes Tested
2
Panel Description
This panel evaluates 2 genes associated with hereditary breast and ovarian cancer (HBOC).
Order This Test
Contact our clinical team to order this panel or learn more.
Indications for Testing
A relevant personal and/or family history suggestive of a hereditary form of cancer.
Methodology
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary breast and ovarian cancer (HBOC).
Technical Specifications
Analytical sensitivity (SNV)
> 99%
Analytical sensitivity (indel)
> 99%
Analytical specificity
> 99%
CNV sensitivity (multi-exon)
> 99%
CNV sensitivity (single-exon)
> 90%
Gene notes
BRCA1: sequencing analysis extends to CDS +/-20 bp; BRCA2: analysis includes detection of c.156_157insAlu and sequencing analysis extends to CDS +/-20 bp.
Genomic build
GRCh38
Genes Tested
2 genes included in this panel
Ordering Information
Turnaround Time
Typically 6-21 days (standard), Typically ≤ 5 days (requery)
Preferred Specimen
BD Vacutainer Whole Blood K2 EDTA Collection Tube 4mL or Oragene Dx Saliva Collection Kit
Shipping Instructions
Specimens to arrive at Helix within 96 hours of collection at ambient temperature.
Clinical Description
This panel evaluates 2 genes associated with hereditary breast and ovarian cancer (HBOC).
Ready to order this test?
Contact our clinical team to order the BRCA1 and BRCA2 Panel for your patients.