Malignant Hyperthermia Susceptibility Panel
This panel evaluates 3 genes associated with malignant hyperthermia.
Turnaround
6-9 days
Requery (SOQO)
≤ 5 days
Genes Tested
3
Panel Description
This panel evaluates 3 genes associated with malignant hyperthermia.
Order This Test
Contact our clinical team to order this panel or learn more.
Indications for Testing
A relevant personal and/or family history suggestive of Malignant Hyperthermia Susceptibility (MHS) or patients preparing to be exposed to anesthetics for the first time.
Methodology
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with Malignant Hyperthermia Susceptibility (MHS).This panel includes 3 genes that are associated with MHS.
Technical Specifications
Analytical sensitivity (SNV)
> 99%
Analytical sensitivity (indel)
> 99%
Analytical specificity
> 99%
CNV sensitivity (multi-exon)
> 99%
CNV sensitivity (single-exon)
> 90%
Gene notes
CACNA1S: Sensitivity to exon 91 may be reduced. STAC3: Sensitivity to exon 7 may be reduced.
Genomic build
GRCh38
Genes Tested
3 genes included in this panel
Ordering Information
Turnaround Time
Typically 6-9 days (standard), Typically ≤ 5 days (requery)
Preferred Specimen
BD Vacutainer Whole Blood K2 EDTA Collection Tube 4mL or Oragene Dx Saliva Collection Kit
Shipping Instructions
Specimens to arrive at Helix within 96 hours of collection at ambient temperature.
Clinical Description
This panel evaluates 3 genes associated with malignant hyperthermia.
Ready to order this test?
Contact our clinical team to order the Malignant Hyperthermia Susceptibility Panel for your patients.