Hereditary Prostate Cancer Panel
A 12-gene panel for assessing hereditary predisposition to prostate cancer, powered by the Helix Exome+® platform for superior variant detection.
Turnaround
6-21 days
Requery (SOQO)
≤ 5 days
Genes Tested
12
Panel Description
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary predisposition to prostate cancer.
Order This Test
Contact our clinical team to order this panel or learn more.
Indications for Testing
A relevant personal and/or family history suggestive of a hereditary form of cancer.
Methodology
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary predisposition to prostate cancer.
Technical Specifications
Analytical sensitivity (SNV)
> 99%
Analytical sensitivity (indel)
> 99%
Analytical specificity
> 99%
CNV sensitivity (multi-exon)
> 99%
CNV sensitivity (single-exon)
> 90%
Gene notes
BRCA1: sequencing analysis extends to CDS +/-20 bp; BRCA2: analysis includes detection of c.156_157insAlu and sequencing analysis extends to CDS +/-20 bp; EPCAM: analysis is limited to CNV of exons 8-9; HOXB13: analysis is limited to the c.251G>A (p.Gly84Glu) variant; MLH1: analysis includes CNV of the promoter; MSH2: analysis includes detection of the Boland inversion (inversion of exons 1-7) and detection of c.942+3A>T; TP53: analysis includes CNV of the promoter.
Genomic build
GRCh38
Genes Tested
12 genes included in this panel
Ordering Information
Turnaround Time
Typically 6-21 days (standard), Typically ≤ 5 days (requery)
Preferred Specimen
BD Vacutainer Whole Blood K2 EDTA Collection Tube 4mL or Oragene Dx Saliva Collection Kit
Shipping Instructions
Specimens to arrive at Helix within 96 hours of collection at ambient temperature.
Clinical Description
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary predisposition to prostate cancer.
Ready to order this test?
Contact our clinical team to order the Hereditary Prostate Cancer Panel for your patients.