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Pharmacogenomics (PGx) Proton Pump Inhibitors CYP2C19 Test

A targeted pharmacogenomic test evaluating CYP2C19 metabolizer status to optimize proton pump inhibitor prescription and dosing, powered by the Helix Exome+® platform.

Turnaround

6-9 days

Turnaround Requery

≤ 5 minutes

Test Description

Proton pump inhibitors are prescribed to patients with gastroesophageal reflux disease (GERD), peptic ulcer disease and other conditions related to dysfunctional gastric acid secretion. Certain CYP2C19 metabolizer types may reduce efficacy of PPIs, while others may lead to increased risk for adverse events.

Patients for whom omeprazole, lansoprazole, pantoprazole, and dexlansoprazole are being considered, have been ineffective or caused side effects.

View the complete description of this test
Sample report

Have Questions?

Our team is available Monday through Friday, 9am-5pm Pacific Time.

(844) 211 2070clinicalsupport@helix.com

Indications for Testing

Patients for whom omeprazole, lansoprazole, pantoprazole, and dexlansoprazole are being considered, have been ineffective or caused side effects.

Methodology

This test utilizes next-generation sequencing to determine star alleles and metabolizer status for CYP2C19 and is used to determine drug considerations for omeprazole, lansoprazole, pantoprazole, and dexlansoprazole.

Technical Specifications

Reportable rangeCYP2C19: *1-*19, *22-*26, *28-*39Results based onDexlansoprazole, CYP2C19 (PGKB 1A); Lansoprazole, CYP2C19 (PGKB 1A; CPIC A); Omeprazole, CYP2C19 (PGKB 1A; CPIC A); Pantoprazole, CYP2C19 (FDA Section 1; CPIC A).

Genes Tested

CYP2C19

Showing 1 of 1 genes in this panel

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Important Test Information

Turnaround time: Typically 7-10 days (standard), Typically < 5 minutes (requery)

Preferred specimen: BD Vacutainer Whole Blood K2 EDTA Collection Tube 4mL or Oragene Dx Saliva Collection Kit

Shipping Instructions: Specimens to arrive at Helix within 96 hours of collection at ambient temperature.

GERD, stomach or duodenal ulcers, H. pylori infection, or other conditions causing stomach acid irritation.

All detected variants are evaluated according to the Clinical Pharmacogenetics Implementation Consortium (CPIC). Variants are classified based on known, predicted, or possible impact on drug metabolism.