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Family Variant Testing

A targeted test to identify specific variants previously identified in a family member, with comprehensive gene evaluation powered by the Helix Exome+® platform.

Turnaround

6-21 days

Turnaround Requery

≤ 5 days

Test Description

Helix Family Variant Testing is a targeted test to identify the presence or absence of one or more specific variants previously identified as being present in a family member. The entire gene will be evaluated and therefore additional variants determined to be pathogenic or likely pathogenic within the gene ordered will also be included in the report. Variants of uncertain significance (VUS) will not be included except in cases where the variant specified in the order is determined to be a VUS. A separate order is required for variants in separate genes.

Have Questions?

Our team is available Monday through Friday, 9am-5pm Pacific Time.

Indications for Testing

A family member of a proband who has received a genetic test result with a pathogenic or likely pathogenic variant.

Methodology

This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants.

Technical Specifications

Analytical sensitivity (SNV)

> 99%

Analytical sensitivity (indel)

> 99%

Analytical specificity

> 99%

CNV sensitivity (multi-exon)

> 99%

CNV sensitivity (single-exon)

> 90%

Gene notes

N/A - Gene-specific notes vary based on the ordered gene.

Genomic build

GRCh38

Genes Available for Testing

ABCA1
ABCC9
ABCD1
ABCG5
ABCG8
ACAD9
ACADVL
ACTA2
ACTC1
ACTN2
ACVRL1
ADAMTS10
AGL
AIP
ALK
ALMS1
ALPK3
ANGPTL3
ANK2
APC
APOA1
APOA5
APOB
APOC2
ATM

Showing 25 of 242 genes in this panel

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