Hereditary Colorectal Cancer Panel
A 19-gene panel for evaluating hereditary predisposition to colon polyps and colorectal cancer, powered by the Helix Exome+® platform for enhanced clinical accuracy.
6-21 days
≤ 5 days
Panel Description
Hereditary predisposition to colorectal polyposis and colorectal cancer refers to the increased likelihood of developing colon cancer and/or numerous polyps in the colon and rectum that may become cancerous. Individuals with a pathogenic variant may also have an increased risk of other cancers such as prostate, ovarian, and uterine, depending on the affected gene.
This panel evaluates 19 genes that have an established, primary association with colon polyps and colorectal cancer.
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Indications for Testing
A personal and/or family history suggestive of a hereditary form of colon polyps and/or colorectal cancer predisposition.
Methodology
This test utilizes next-generation sequencing to detect single nucleotide variants, insertions and deletions up to 20 bp, and copy number variants in genes associated with hereditary forms of polyposis and colorectal cancer.
Technical Specifications
> 99%
> 99%
> 99%
> 99%
> 90%
APC: analysis includes CNV of promoters 1A and 1B and sequencing of promoter 1B; BMPR1A: analysis includes CNV of promoter; EPCAM: analysis is limited to CNV of exons 8-9; GREM1: analysis is limited t...
GRCh38
Genes Tested
Showing 19 of 19 genes in this panel