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HELIX DIAGNOSTICS

Comprehensive Carrier Screen

Test Description

The Helix Comprehensive Carrier Screen analyzes 278 genes associated with a broad range of serious inherited conditions, aligned with ACMG Tier 4 guidelines. This extensive panel provides the most thorough carrier screening option, covering prevalent and clinically significant inherited disorders.

Genes Tested (278)

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ABCA3
ABCC8
ABCD1
ACADM
ACADS
ACADVL
ACAT1
ADA
ADAMTS2
AGA
AGL
AGXT
AHI1
AIRE
ALDH3A2
ALDOB
ALG6
ALMS1
ALPL
AMT
ANO10
ARG1
ARSA
ARSB
ARX
ASL
ASNS
ASPA
ASS1
ATM
ATP6V1B1
ATP71
ATP7B
BBS1
BBS10
BBS12
BBS2
BCKDHA
BCKDHB
BCS1L
BLM
BTD
CAPN3
CBS
CC2D2A
CCDC88C
CDH23
CEP290
CERKL
CFTR
CHM
CHRNE
CLCN1
CLN3
CLN5
CLN6
CLN8
CLRN1
CNGB3
COL4A3
COL4A4
COL4A5
COL7A1
CPS1
CPT1A
CPT2
CRYL1
CTNS
CTSK
CYBA
CYP11A1
CYP11B1
CYP11B2
CYP21A2
CYP27A1
CYP27B1
DBT
DCLRE1C
DHCR7
DHDDS
DLD
DMD
DNAH5
DNAI1
DNAI2
DPYD
DYNC2H1
DYSF
ELP1
ERCC2
ERCC6
ERCC8
ETHE1
EVC
EVC2
EYS
F11
F9
FAH
FAM161A
FANCA
FANCC
FKRP
FKTN
FMO3
FMR1
G6PC
GAA
GALC
GALK1
GALNS
GALT
GAMT
GBA
GBE1
GCDH
GJB1
GJB2
GJB6
BLA
GLB1
GLDC
GLE1
GNE
GNPTAB
GNPTG
GNS
GRHPR
GRIP1
GUSB
HADHA
HBA1
HBA2
HBB
HEXA
HEXB
HGD
HGSNAT
HLCS
HMGCL
HOGA1
HPS1
HPS3
HSD17B4
HYLS1
IDS
IDUA
IL2RG
IVD
KCNJ11
L1CAM
LAMA2
LAMA3
LAMB3
LAMC2
LIPA
LOXHD1
LRP2
LRPPRC
MAN2B1
MCCC1
MCCC2
MCOLN1
MCPH1
MED17
MEFV
MESP2
MID1
MLC1
MMAA
MMAB
MMACHC
MUT
MPL
MTHFR
MTM1
MTTP
MVK
MYO7A
NAGA
NAGLU
NBN
NDUFAF5
NDUFS4
NDUFS6
NEB
NPC1
NPC2
NPHS1
NPHS2
NR0B1
NR2E3
NTRK1
OAT
OCA2
OPA3
OTC
PAH
PC
PCCA
PCCB
PCDH15
PDHA1
PEX1
PEX10
PEX12
PEX2
PEX26
PEX6
PEX7
PFKM
PHGDH
PKHD1
PLP1
PMM2
POLG
POMGNT1
PPT1
PRF1
PROP1
PTS
PUS1
PYGN
RAG1
RAG2
RAPSN
RARS2
RMRP
RNASEH2B
RPE65
RS1
RTEL1
SACS
SCO2
SEPSECS
SGCA
SGCB
SGCD
SGCG
SGSH
SLC12A6
SLC17A5
SLC19A3
SLC22A5
SLC25A13
SLC25A20
SLC26A2
SLC26A4
SLC35A3
SLC37A4
SLC6A8
SLC7A7
SMN1
SMPD1
STAR
SUMF1
SURF1
TAT
TCIRG1
TECPR2
TF
TGM1
TH
TMEM216
TPP1
TRMU
TTPA
TYMP
USH1C
USH2A
VPS13A
VPS13B
VRK1
VSX2
WNT10A
XPA
XPC
ZFYVE26

Important Panel Information

Turnaround time: Typically 7 to 21 days

Preferred specimen: Oragene Dx Saliva Collection Kit

Shipping instructions: Specimens to arrive at Helix within 96 hours of collection at ambient temperature.

This panel includes genes that have an established association with the autosomal recessive or X-linked conditions described in the panel description here.

Variants are interpreted manually using locus-specific databases, literature searches, and other molecular biological principles. Variants classified as pathogenic, likely pathogenic, or risk allele which are located in the coding regions and nearby intronic regions (+/- 20 bp) of the genes listed are reported. Variants of uncertain significance (VUSes) are not reported.

Other Tests to Consider

Fundamental Carrier Screen

2 genes

Core Carrier Screen

39 genes

Expanded Carrier Screen

115 genes