Mayo Clinic GeneGuide™

by Mayo Clinic

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Mayo Clinic GeneGuide™ is a genetic testing experience that helps you understand how genetics can affect your health. Get personalized insights, interactive tools and education that help you explore the health information in your DNA, carrier screening, disease risk, family health history and more.

$199.99 $149.99
Price includes $25.00 collected for an independent physician to review and determine whether the test is appropriate for you, and for genetic counseling services.
To use this product, you must be 18 or older and be a U.S. resident. Not available for residents of New York.
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Includes a DNA kit for first-time users.


Sign in

No need for another DNA kit. Sign in​ to get started.

More than a genetic test

Your genes tell a fascinating story about your health and potential risk of certain diseases and conditions.

• Dive into friendly education.
• Explore your genetic testing results.
• Engage with interactive tools.
• Build valuable knowledge.

Insights you can trust

Results are private and secure, backed by the expertise and accuracy of the world-class genetic counselors, doctors, and health care professionals at Mayo Clinic. If you have questions, genetic counselor support is available from independent provider network PWNHealth throughout the testing experience.

What's Included

Carrier screening 

• GJB2-related hearing loss
</br>• Cystic fibrosis 
</br>• Medium-chain acyl-CoA dehydrogenase deficiency 
</br>• Sickle cell disease 

Disease risk 

• Age-related macular degeneration 
</br>• Atrial fibrillation 
</br>• Coronary artery disease 
</br>• Venous thromboembolism 

Medication response 

• Ibuprofen metabolism
</br>• Omeprazole metabolism
</br>• Pseudocholinesterase deficiency 
</br>• Malignant hyperthermia 

Health traits  

• Alcohol flush reaction
</br>• Atopic dermatitis 
</br>• Lactase persistence 


• Health ancestry 
</br>• Breast Cancer Referral Screening Tool (not a genetic test) 
</br>• Lifestyle Risk Assessment 
</br>• Pedigree (build a family tree to document your family’s health history) 


• 15 topics in four categories 
</br>• In-depth information about conditions

Features of Mayo Clinic GeneGuide™

Genetic results information: Mayo Clinic GeneGuide™ allows you to understand how your genetics may impact your risks of certain health conditions. It provides you with information and tools that aid your understanding of potential health risks, including potential risks of complex illness, how certain conditions may be passed on from generation to generation, your genetic response to certain medications, your health traits, and more.

Easy-to-understand reports and educational materials: Reveal the meaning and impact of genetic testing results for the conditions tested.

Mayo Clinic expertise: Mayo Clinic's team of physicians, medical geneticists, and genetic counselors developed this product to provide genetic health insights to you. Mayo Clinic hopes what you learn through this product will inspire you to take action that will improve your health.

Your data: Mayo Clinic does not sell your data to third parties for commercial purposes or use information for medical research without your explicit consent.

The science

This product looks at DNA variants that influence health conditions in different ways.

The carrier screening results allow you to check if you are carrying a variant that leads to a non-working copy of a gene. If two people carry a non-working copy of the same gene, their children may inherit a resulting autosomal recessive disorder.

The disease risk results inform you how your genetics, your lifestyle, and other factors (such as smoking habit, BMI, and blood pressure) influence your risk for some common complex diseases, such as age-related macular degeneration. These diseases are called “complex” because their cause is rarely due to a simple DNA variant, or a single environmental factor. Many DNA variants have been shown to each have a small influence, and many other factors are known to be involved.

The medication response results will tell you whether you have variants that influence how your body metabolizes some drugs. In some cases, DNA variants can make you metabolize and degrade a drug very quickly, and in other cases, your body may take longer than average to get rid of the drug.


This product provides information about results for some health conditions that are mostly influenced by genetics, and for other health conditions where genetics, environment, and lifestyle all influence your disease risk.


  • Mayo Clinic GeneGuideTM is not a diagnostic product.
  • This product evaluates specific variants associated with 15 different health conditions and medication response. It does not look at all possible genes or variants associated with each condition tested.
  • This product does not evaluate for gene variants associated with conditions not included in the test.

How it works

Your Helix saliva collection kit ships within two days. Once Helix receives your saliva sample, they begin sequencing your DNA. Through our seamless process, your order requires a review of your related health history and test order from PWNHealth.

No paperwork required

Answer a few questions about your health history during product registration. It takes just a few minutes.

No additional cost

The review of your health history adds no additional cost to your test, and insurance isn’t required.
Order your product
Helix sends a DNA kit to your home
Register your product and provide your health history
Provide a saliva sample and a physician will review your information
Get an email when your results are ready

The Helix DNA kit

To capture the information stored in your DNA so it can be used for this product, we need to collect a small, one-time saliva sample from you. This kit has everything you need to provide that sample from the comfort of your own home, and you’ll never have to provide another.

  • A unique Kit ID you’ll use to register your kit

  • Saliva collection tube, cap, and printed instructions

  • A small bag and prepaid box to send your saliva sample to our lab

About Mayo Clinic

Mayo Clinic is a nonprofit organization committed to providing expert, whole-person care to everyone who needs healing. The Mayo Clinic mission is to inspire hope and contribute to health and well-being by providing the best care to every patient through integrated clinical practice, education and research.

For more information, visit or

About Helix

Helix empowers everyone to explore what makes them unique—their DNA.

From health and wellness insights to family planning and ancestry information, Helix’s growing list of partners can tap into your genetic profile to provide relevant insights for today, tomorrow and years to come.

Have a question about ordering or sequencing?


  • Are the tests and results comprehensive?

    The genes, variants and conditions included in the Mayo Clinic GeneGuide™ testing experience are scientifically robust and include common genetic changes that are associated with each tested condition in Mayo Clinic GeneGuide™. Each variant was carefully selected by our expert genetics team. Mayo Clinic GeneGuide™ does not evaluate the entire human genome. Therefore, a risk remains that you may have variants for which Mayo Clinic GeneGuide™ does not test.

  • What variants and conditions does Mayo Clinic GeneGuide™ cover?

    Mayo Clinic GeneGuide™ tests for variants known to impact health and wellness. Please visit Mayo Clinic GeneGuide™ to view a list of the variants and conditions tested.

  • Does Mayo Clinic sell my data?

    Mayo Clinic GeneGuide™ does not sell your data to third-party organizations nor use it for health-related research without your consent.

  • Who can see my results?

    Your results and reports are confidential. Only you, the Mayo Clinic GeneGuide™ laboratory and PWNHealth have access to your results.

  • How do you ensure the safety of my genetic materials and reports?

    Information security processes are in place to prevent unauthorized access, use, disclosure, disruption, modification, inspection, recording or destruction of health information.

  • Should I share my results with my health care provider?

    Mayo Clinic GeneGuide™ is designed to help you find information and answers about your genetics to guide you in making more-educated health and lifestyle choices. Mayo Clinic recommends discussing the results, concerns and lifestyle changes with your family physician or a specialist.

  • Can I have my child tested using Mayo Clinic GeneGuide™?

    No. Individuals must be 18 years or older to use Mayo Clinic GeneGuide™.

  • What if Mayo Clinic GeneGuide™ doesn't identify any variants in my DNA?

    If Mayo Clinic GeneGuide™ does not identify any variants in your DNA, your risk of developing the conditions tested for by Mayo Clinic GeneGuide™ can be reduced, but does not go away. This is because you could potentially have genetic changes (variants) for which Mayo Clinic GeneGuide™ does not test. As part of your purchase, you will have access to the valuable tools and educational materials included in Mayo Clinic GeneGuide™.

  • Is Mayo Clinic GeneGuide™ and genetic testing covered under my insurance?

    Mayo Clinic GeneGuide™ is not covered under most insurance plans.

  • How do I get my results?

    You will be notified via email when your results are ready to view in the secure online environment for Mayo Clinic GeneGuide™.

  • What if I have questions or concerns about my results?

    Once you’ve purchased Mayo Clinic GeneGuide™, PWNHealth genetic counselors are available to answer your questions.

  • Why do I need a PWNHealth physician to order this test for me?

    Mayo Clinic GeneGuide™ is not a direct-to-consumer genetic test approved by the U.S. Food and Drug Administration. Health care providers from PWNHealth ensure that this test is appropriate for you in light of your personal and family history.

  • How long does it take for my test request to be reviewed and ordered by a PWNHealth physician?

    You will be notified whether your test order has been approved by PWNHealth within one business day of completing the required health questionnaire.

  • I'm already a Helix customer. Will I need to submit another sample in order to use this product?

    Most current Helix customers will not need to submit another sample in order to use Mayo Clinic GeneGuide, but in some cases, we may require a new sample. In this situation, Helix will send a new saliva collection kit to you at no charge. Click here to learn more.

  • How do I learn more about how Mayo Clinic uses my information?

    You can learn more in the Mayo Clinic Terms of ServicePrivacy Policy, and Product Consent.