Alzheimer's ApoE

by ADx Healthcare

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In the fight against late-onset Alzheimer’s disease, early awareness can make a difference in taking care of your future self. A consultation with a genetic counselor is included to help you better understand your risk.

$199.99 $159.00
Price includes $35.00 collected for an independent physician to review and determine whether the test is appropriate for you, and for genetic counseling services.
To use Helix, you must be 18 or older and have a U.S. shipping address. Not available for residents of Maryland, New Jersey, New York, Pennsylvania, or Rhode Island.
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ALZHEIMER'S DISEASE

Protect your future self

Good For: Those with a family member who has been diagnosed with Alzheimer’s or some other form of dementia, or anyone who wants to understand their personal risk for late-onset Alzheimer’s disease.

What to Expect: A result based on your combination of ApoE alleles that calculates your ApoE-related genetic risk for late-onset Alzheimer’s disease, based on genetics and age.

Value: Better understand your risk for developing late-onset Alzheimer’s disease, allowing you to make adjustments in your lifestyle that could reduce or delay the condition’s development later in life.

What is Alzheimer's disease?

Alzheimer’s disease is a progressive form of dementia that is characterized by tau proteins and plaques in the brain that result in brain cell death over time. Scientists believe that for most people the development of Alzheimer’s disease is caused by a combination of genetic, lifestyle, and environmental factors

Why learn more about your risk?

Research indicates that lifestyle behaviors across your life span may contribute to the development of Alzheimer’s disease.

Also, changes occur in the brain up to two decades before the first symptoms develop. Because Alzheimer’s is believed to be caused by a combination of environmental, genetic, and lifestyle factors, learning your genetic risk can help you determine how aggressively you need to make lifestyle changes to reduce your risk.

The earlier in your life that you commit to living a healthy lifestyle, the more you can reduce your risk for or delay the development of Alzheimer’s disease.

Who is at risk for Alzheimer's disease?

– If you have a family member who has been diagnosed with Alzheimer’s or some other form of dementia, you are likely concerned about your own personal risk too.

– Families share a living environment and lifestyle, in addition to their genetics.

– Scientists believe late-onset Alzheimer’s disease (occurring in the mid-60’s and older) involves a combination of genetics, lifestyle, and environment.

– A family history of Alzheimer’s does not mean that you will develop the disease, but it may mean that you are more likely to develop it.

I heard there isn’t a cure, but why haven’t I heard that I can reduce my risk for Alzheimer’s disease?

There is not a single universally accepted standard of care for diagnosing or treating Alzheimer’s disease in the US. This leaves many patients seeking answers on their own.

Emerging research can take a while to be accepted by mainstream healthcare providers. You may have seen headlines on news shows or on the internet highlighting some of the scientific breakthroughs on modifiable risk factors for Alzheimer’s disease, but may have not heard about them elsewhere yet. Also, because genetic testing for Alzheimer’s disease is still not covered by insurance, many medical practices are not equipped to handle these evaluation paths yet.

You aren’t limited by what your doctor’s office offers or what your insurance will cover. Genetic testing is now available through private pay, and there are telehealth physicians available to help you determine if the Alzheimer’s disease genetic test is a good fit for you.

What will my results tell me?

Your test results will explain which combination of ApoE alleles you have. This genetic combination will help you identify your ApoE-related genetic risk for developing late-onset Alzheimer’s disease, based on your ApoE genotype and your current age.

Your ApoE status will not change as you age, but as you age your chance of developing Alzheimer’s will increase at a different rate dependent on which ApoE combination you have.

A genetic counselor will be available to go through your results with you if you have questions.

The science

Late-onset Alzheimer's disease is diagnosed after the age of 65 and is the most common form of Alzheimer disease1. Through years of research, scientists have studied patients with Alzheimer's disease and compared them with other individuals of the same age without Alzheimer's disease to identify genes that predispose them to late-onset Alzheimer's disease. The research led to the discovery that variants in the APOE gene are associated with the risk of late-onset Alzheimer's disease. A genotype based on variants at two different positions in your DNA (named APOE-e4) increases one's risk, while a different genotype (named APOE-e2) is associated with a lower risk for late-onset Alzheimer disease2,3. Scientists are still working to understand the precise biological mechanism connecting the APOE gene and the risk to develop Alzheimer's disease.

The genetic association between APOE e2/e3/e4 and late-onset Alzheimer's disease has been replicated in numerous studies looking at independent populations, including different ancestries, and performed by independent scientists3, 4, 5. However, the current risk estimates are more precise for European populations as they were calculated on a larger number of individuals.

Impact

Genes, lifestyle, environment, medical factors, and age all influence your risk for late-onset Alzheimer’s disease.

Limitations

  • The results of this test do not diagnose Alzheimer’s disease, or any other type of dementia. This is not a diagnostic product.
  • This product does not look at all possible genes or variants associated with late-onset Alzheimer’s disease. It reports on the most important known genetic factor associated with late-onset Alzheimer’s disease.
  • This product does not look at variants in the APP, PSEN1, PSEN2 genes, which are associated with early-onset Alzheimer’s disease.
  • This product provides you with your genetic risk for Alzheimer’s disease. It does not provide detailed information on other traits associated with APOE variants.

How it works

Because this test screens for conditions that might have serious medical implications, ADx Healthcare provides a physician to review your health history to ensure it’s right for you before testing.

No paperwork

Answer a few questions about your health history during product registration. It takes just a few minutes.

No additional cost

The review of your health history adds no additional cost to your test, and insurance isn’t required.
Order your product
Helix sends a DNA kit to your home
Register your product and provide your health history
Provide a saliva sample and a physician will review your information
Get an email when your results are ready

The Helix DNA kit

To capture the information stored in your DNA so it can be used for this product, we need to collect a small, one-time saliva sample from you. This kit has everything you need to provide that sample from the comfort of your own home, and you’ll never have to provide another.

  • A unique Kit ID you’ll use to register your kit

  • Saliva collection tube, cap, and printed instructions

  • A small bag and prepaid box to send your saliva sample to our lab

References

1
Genetics Home Reference. “Alzheimer disease” Accessed July 30, 2018. https://ghr.nlm.nih.gov/condition/alzheimer-disease
2
Genetics Home Reference. “APOE gene” Accessed July 30, 2018. https://ghr.nlm.nih.gov/gene/APOE#
3
Genin E. et al., “APOE and Alzheimer’s disease: a major gene with semi-dominant inheritance.” Mol Psychiatry, 2011, 16: 903-907. DOI: 10.1038/mp.2011.52
4
Corder EH. et al., “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families.”, Science, 1993, 261(5123): 921-923. DOI: 10.1126/science.8346443
5
Bonham LW. et al., “Age-dependent effects of APOE e4 in preclinical Alzheimer’s disease”, Ann Clin Transl Neurol, 2016, 3(9): 667-77. DOI: 10.1002/acn3.333
6
Ngandu T. et al., A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomized controlled trial. The Lancet. 2014; 386: 2255-2263.
7
PLOS Collections. Dementia: Across the Lifespan and Around the Globe. Collection of articles on Alzheimer’s disease and dementia. Published March 2017. http://collections.plos.org/dementia. Accessed September 23, 2017.
8
Clare L, Wu YT, Teale JC, et al. Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study. PLoS Med. 2017;14(3):e10022259.

About ADx Healthcare

ADx Healthcare is passionate about bringing education, wellness, and hope to those who are affected by Alzheimer’s disease and other cognitive disorders. We seek to bring the latest health-conscious science to those with early stage cognitive decline or genetic predispositions for these disorders. We do this by educating and supporting these individuals, utilizing the most recent scientific knowledge on diet, lifestyle, and other key factors for maximizing brain health and fighting the effects of neurodegenerative disease.

About Helix

Helix empowers everyone to explore what makes them unique—their DNA.

From health and wellness insights to family planning and ancestry information, Helix’s growing list of partners can tap into your genetic profile to provide relevant insights for today, tomorrow and years to come.

Have a question about ordering or sequencing?support@helix.com

Questions

  • What form of Alzheimer’s disease does this test for?

    The Alzheimer’s ApoE Test will help people determine their genetic risk for the most common form of the disease: non-familial (“sporadic”) Alzheimer’s.

    By contrast, when people talk about the “hereditary” or “familial” form of Alzheimer’s disease, they are usually talking about a very rare form of the disease (only about 1% of all cases) that is caused by an abnormality in one of three specific genes – PS1, PS2, or APP. This form is also referred to as early-onset familial Alzheimer’s disease (eFAD). This is not the form we’re talking about with ApoE testing. ApoE is a risk factor for the non-familial (also called “sporadic”) form of Alzheimer’s disease, which is the most common form of the disease.

  • Do I have to get sequenced to use this product?

    Yes. In order to use the Alzheimer’s ApoE Test by ADx Healthcare, you must be sequenced by Helix. To ensure the quality and accuracy of the genetic information used for this service, products in the Helix marketplace do not accept genetic data from outside sources. And, once you’ve been sequenced by Helix, you can purchase more DNA-powered products from a variety of categories like fitness, nutrition, entertainment, and more—all without having to get sequenced again.

  • How does Helix provide my DNA information to ADx Healthcare? Is it shared with anyone else?

    Your DNA information is stored securely by Helix. When sequencing is complete, Helix only sends the relevant DNA information needed by ADx Healthcare to generate your results. We do not share your DNA information with anyone without your permission. We always maintain high standards when it comes to the security and privacy of your DNA information.

  • How do I learn more about how ADx Healthcare uses my information?

    You can learn more in the ADx Healthcare Privacy PolicyTerms of Service, and Product Consent.

  • Can I choose my own physician to approve testing?

    No. When you order Alzheimer’s ApoE Test, you answer relevant health history questions. Helix will share your contact information and health history with ADx Healthcare so a physician they designate can review and make sure this product is right for you. This process helps make sure you get access to these insights quickly and efficiently through a provider that is familiar with this type of testing. You can always share your results with your healthcare providers.

  • Do I need access to my medical records to answer the health history questions?

    While it might help to have your records handy, it’s definitely not required. It’s okay to answer the health history questions from memory to the best of your ability.

  • Can I use my health insurance benefits to purchase this product?

    Unfortunately, no. This is an at-home test that doesn’t require an office visit, and we cannot currently accept payment from insurance providers.

  • Will someone be available to help me understand my results?

    You will receive your test results in a clear report. However, if you have additional questions about what the results mean to you or your family, we have independent genetics counselors available to discuss your results with you, for no additional charge. Also, we encourage you to share your report with your physician and review with them any additional questions or concerns you may have.

  • What genes does this product check?

    The Alzheimer’s ApoE test is a single gene test that looks at your ApoE-related genetic risk for Alzheimer’s disease. There are other genes that play a role in Alzheimer’s risk but the ApoE gene is believed to be the largest contributing genetic factor. Having a high risk copy of this gene (ApoE-e4) does not guarantee that you will develop Alzheimer’s disease. Likewise, possessing a copy of the lowest risk variant (ApoE-e2) does not mean you won’t develop Alzheimer’s disease. Alzheimer’s disease risk is also influenced by other genes, other medical conditions, age, gender, and environmental and lifestyle factors, so learning your ApoE-related genetic risk is only one part of an assessment of risk. Knowing your overall risk can help you decide how aggressively you want to address your cognitive health.